Drug interactions
Amitriptyline + Oxcarbazepine
Severity: Minor
Amitriptyline and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can induce CYP3A4 and may lower amitriptyline exposure, and it may also inhibit CYP2C19 and shift metabolism of amitriptyline to its metabolite. The net effect is variable and usually modest. Reduced antidepressant effect is possible.
What this interaction means in plain words
Amitriptyline and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine's metabolite induces CYP3A4 and weakly inhibits CYP2C19, altering amitriptyline metabolism.
What to do
Monitor clinical response and for anticholinergic or sedative effects. Consider adjusting the amitriptyline dose or measuring levels if response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Amitriptyline with Oxcarbazepine?
MediHelp rates the interaction as minor. Amitriptyline and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine can induce CYP3A4 and may lower amitriptyline exposure, and it may also inhibit CYP2C19 and shift metabolism of amitriptyline to its metabolite. The net effect is variable and usually modest. Reduced antidepressant effect is possible.
How serious is the interaction between Amitriptyline and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and for anticholinergic or sedative effects. Consider adjusting the amitriptyline dose or measuring levels if response changes.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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