Drug interactions
Amitriptyline + Quizartinib
Severity: Major
Amitriptyline and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes dose-dependent QT prolongation and amitriptyline can prolong the QT interval as well. Used together, they increase the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Amitriptyline and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid the combination where possible, and if it must be used, monitor ECG closely and keep potassium and magnesium within normal range. Reduce the quizartinib dose or interrupt therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amobarbital + Quizartinib Major
- Apalutamide + Quizartinib Major
Frequently asked questions
Can I take Amitriptyline with Quizartinib?
MediHelp rates the interaction as major. Amitriptyline and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes dose-dependent QT prolongation and amitriptyline can prolong the QT interval as well. Used together, they increase the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Amitriptyline and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and if it must be used, monitor ECG closely and keep potassium and magnesium within normal range. Reduce the quizartinib dose or interrupt therapy if QTc becomes markedly prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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