Drug interactions
Amitriptyline + Scopolamine
Severity: Moderate
Amitriptyline and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are strongly anticholinergic, so together they may cause dry mouth, constipation, urinary retention, tachycardia, blurred vision, confusion and, in severe cases, delirium or ileus. Older adults and those with glaucoma or prostatic hypertrophy are at particular risk.
What this interaction means in plain words
Amitriptyline and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity and avoid the combination in older adults or patients with narrow-angle glaucoma or urinary obstruction. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Scopolamine?
MediHelp rates the interaction as moderate. Amitriptyline and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are strongly anticholinergic, so together they may cause dry mouth, constipation, urinary retention, tachycardia, blurred vision, confusion and, in severe cases, delirium or ileus. Older adults and those with glaucoma or prostatic hypertrophy are at particular risk.
How serious is the interaction between Amitriptyline and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and avoid the combination in older adults or patients with narrow-angle glaucoma or urinary obstruction. Use the lowest effective doses.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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