Drug interactions
Amitriptyline + Telavancin
Severity: Moderate
Amitriptyline and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so the combination may increase risk of ventricular arrhythmias including torsades de pointes. Risk is higher with high amitriptyline doses, heart disease or electrolyte imbalance.
What this interaction means in plain words
Amitriptyline and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation.
What to do
Check baseline ECG and monitor QTc, and correct hypokalemia and hypomagnesemia. Avoid in patients with congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Telavancin?
MediHelp rates the interaction as moderate. Amitriptyline and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so the combination may increase risk of ventricular arrhythmias including torsades de pointes. Risk is higher with high amitriptyline doses, heart disease or electrolyte imbalance.
How serious is the interaction between Amitriptyline and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and monitor QTc, and correct hypokalemia and hypomagnesemia. Avoid in patients with congenital long QT syndrome.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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