Drug interactions
Amitriptyline + Zuranolone
Severity: Moderate
Amitriptyline and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired psychomotor performance, and amitriptyline adds sedative effects. Together they may cause excessive drowsiness and impair driving or other tasks.
What this interaction means in plain words
Amitriptyline and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and tricyclic antihistaminic and sedative effects.
What to do
Monitor for excessive sedation and consider lowering the dose of one or both drugs. Counsel patients not to drive or operate machinery for the period specified in the zuranolone labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Amitriptyline with Zuranolone?
MediHelp rates the interaction as moderate. Amitriptyline and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired psychomotor performance, and amitriptyline adds sedative effects. Together they may cause excessive drowsiness and impair driving or other tasks.
How serious is the interaction between Amitriptyline and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider lowering the dose of one or both drugs. Counsel patients not to drive or operate machinery for the period specified in the zuranolone labeling.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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