Drug interactions
Amlodipine + Atracurium
Severity: Minor
Amlodipine and Atracurium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can enhance the effect of nondepolarizing neuromuscular blockers. With amlodipine, any potentiation of atracurium is likely modest but could prolong paralysis.
What this interaction means in plain words
Amlodipine and Atracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Atracurium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, adding to nondepolarizing block.
What to do
Titrate atracurium to nerve stimulator response and allow for a possibly longer duration of blockade.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Atracurium?
MediHelp rates the interaction as minor. Amlodipine and Atracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can enhance the effect of nondepolarizing neuromuscular blockers. With amlodipine, any potentiation of atracurium is likely modest but could prolong paralysis.
How serious is the interaction between Amlodipine and Atracurium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate atracurium to nerve stimulator response and allow for a possibly longer duration of blockade.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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