Drug interactions
Amlodipine + Bretylium
Severity: Moderate
Amlodipine and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium blocks norepinephrine release from sympathetic nerve terminals and commonly causes hypotension, including orthostatic hypotension. Amlodipine adds vasodilation, so combined use can produce more pronounced drops in blood pressure.
What this interaction means in plain words
Amlodipine and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from adrenergic neuron blockade and calcium channel blocker vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms closely, especially after starting or changing either drug. Reduce the amlodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Bretylium?
MediHelp rates the interaction as moderate. Amlodipine and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium blocks norepinephrine release from sympathetic nerve terminals and commonly causes hypotension, including orthostatic hypotension. Amlodipine adds vasodilation, so combined use can produce more pronounced drops in blood pressure.
How serious is the interaction between Amlodipine and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms closely, especially after starting or changing either drug. Reduce the amlodipine dose if hypotension develops.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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