Drug interactions
Amlodipine + Butalbital
Severity: Minor
Amlodipine and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that induces CYP3A4 and may lower amlodipine concentrations, with possible loss of blood pressure or angina control. The effect is greater with frequent or prolonged use.
What this interaction means in plain words
Amlodipine and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated CYP3A4 induction increases amlodipine metabolism.
What to do
Monitor blood pressure if butalbital is used regularly, and adjust amlodipine if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Butalbital?
MediHelp rates the interaction as minor. Amlodipine and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that induces CYP3A4 and may lower amlodipine concentrations, with possible loss of blood pressure or angina control. The effect is greater with frequent or prolonged use.
How serious is the interaction between Amlodipine and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if butalbital is used regularly, and adjust amlodipine if control worsens.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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