Drug interactions
Amlodipine + Calcium chloride
Severity: Moderate
Amlodipine and Calcium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium salts given parenterally can raise ionized calcium and partly oppose the blood pressure lowering effect of amlodipine. Intravenous calcium has been used to reverse calcium channel blocker toxicity, which illustrates the antagonism. Oral calcium supplements rarely cause a meaningful loss of antihypertensive effect.
What this interaction means in plain words
Amlodipine and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased extracellular calcium pharmacodynamically opposes calcium channel blockade at vascular smooth muscle.
What to do
Monitor blood pressure when intravenous calcium is given to patients taking amlodipine, and expect a reduced antihypertensive response. Avoid giving unnecessary calcium boluses and check serum calcium if hypercalcemia is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Calcium chloride?
MediHelp rates the interaction as moderate. Amlodipine and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium salts given parenterally can raise ionized calcium and partly oppose the blood pressure lowering effect of amlodipine. Intravenous calcium has been used to reverse calcium channel blocker toxicity, which illustrates the antagonism. Oral calcium supplements rarely cause a meaningful loss of antihypertensive effect.
How serious is the interaction between Amlodipine and Calcium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when intravenous calcium is given to patients taking amlodipine, and expect a reduced antihypertensive response. Avoid giving unnecessary calcium boluses and check serum calcium if hypercalcemia is suspected.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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