Drug interactions
Amlodipine + Cenobamate
Severity: Moderate
Amlodipine and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4, which may lower amlodipine plasma concentrations and weaken blood pressure or angina control. The effect may develop gradually after cenobamate titration and persist for a while after it is stopped.
What this interaction means in plain words
Amlodipine and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by cenobamate increases amlodipine metabolism.
What to do
Monitor blood pressure and anginal symptoms when cenobamate is started or titrated, and increase the amlodipine dose if needed. Reassess the dose if cenobamate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Amlodipine with Cenobamate?
MediHelp rates the interaction as moderate. Amlodipine and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4, which may lower amlodipine plasma concentrations and weaken blood pressure or angina control. The effect may develop gradually after cenobamate titration and persist for a while after it is stopped.
How serious is the interaction between Amlodipine and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms when cenobamate is started or titrated, and increase the amlodipine dose if needed. Reassess the dose if cenobamate is withdrawn.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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