Drug interactions
Amlodipine + Dabrafenib
Severity: Moderate
Amlodipine and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may reduce amlodipine exposure, which can lead to reduced antihypertensive or antianginal effect.
What this interaction means in plain words
Amlodipine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, accelerating amlodipine metabolism.
What to do
Monitor blood pressure after starting dabrafenib and increase the amlodipine dose if control is lost. Re-evaluate the dose when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Amlodipine with Dabrafenib?
MediHelp rates the interaction as moderate. Amlodipine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may reduce amlodipine exposure, which can lead to reduced antihypertensive or antianginal effect.
How serious is the interaction between Amlodipine and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting dabrafenib and increase the amlodipine dose if control is lost. Re-evaluate the dose when dabrafenib is stopped.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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