Drug interactions
Amlodipine + Diltiazem
Severity: Moderate
Amlodipine and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and raises amlodipine exposure, intensifying vasodilatory effects. This can cause hypotension, edema and dizziness, and the added effect on the sinus and AV nodes from diltiazem is relevant in susceptible patients.
What this interaction means in plain words
Amlodipine and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of amlodipine, with additive calcium channel blockade.
What to do
Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension occurs. Be especially watchful in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Amlodipine with Diltiazem?
MediHelp rates the interaction as moderate. Amlodipine and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and raises amlodipine exposure, intensifying vasodilatory effects. This can cause hypotension, edema and dizziness, and the added effect on the sinus and AV nodes from diltiazem is relevant in susceptible patients.
How serious is the interaction between Amlodipine and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension occurs. Be especially watchful in elderly patients.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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