Drug interactions
Amlodipine + Doxazosin
Severity: Moderate
Amlodipine and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs lower blood pressure through different mechanisms and are sometimes used together deliberately. The combination can nevertheless cause additive hypotension, dizziness and peripheral edema, particularly at initiation or in older patients.
What this interaction means in plain words
Amlodipine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing doses, and titrate doxazosin gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Doxazosin?
MediHelp rates the interaction as moderate. Amlodipine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs lower blood pressure through different mechanisms and are sometimes used together deliberately. The combination can nevertheless cause additive hypotension, dizziness and peripheral edema, particularly at initiation or in older patients.
How serious is the interaction between Amlodipine and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing doses, and titrate doxazosin gradually.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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