Drug interactions
Amlodipine + Encorafenib
Severity: Moderate
Amlodipine and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so amlodipine exposure may rise or fall unpredictably. This can cause hypotension and edema or reduced blood pressure control. Encorafenib can also cause QT prolongation and hypertension.
What this interaction means in plain words
Amlodipine and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters amlodipine metabolism.
What to do
Monitor blood pressure regularly and adjust the amlodipine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Encorafenib
Frequently asked questions
Can I take Amlodipine with Encorafenib?
MediHelp rates the interaction as moderate. Amlodipine and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so amlodipine exposure may rise or fall unpredictably. This can cause hypotension and edema or reduced blood pressure control. Encorafenib can also cause QT prolongation and hypertension.
How serious is the interaction between Amlodipine and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly and adjust the amlodipine dose according to response.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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