Drug interactions
Amlodipine + Fosamprenavir
Severity: Moderate
Amlodipine and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (amprenavir), especially when boosted with ritonavir, inhibits CYP3A4 and can raise amlodipine levels. This may cause hypotension and edema.
What this interaction means in plain words
Amlodipine and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir and ritonavir inhibit CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure and edema and use a lower starting dose of amlodipine; titrate to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Fosamprenavir?
MediHelp rates the interaction as moderate. Amlodipine and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (amprenavir), especially when boosted with ritonavir, inhibits CYP3A4 and can raise amlodipine levels. This may cause hypotension and edema.
How serious is the interaction between Amlodipine and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and use a lower starting dose of amlodipine; titrate to effect.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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