Drug interactions
Amlodipine + Grapefruit
Severity: Minor
Amlodipine and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice can modestly raise amlodipine concentrations by inhibiting intestinal CYP3A4. The increase is small and seldom produces a meaningful change in blood pressure or adverse effects.
What this interaction means in plain words
Amlodipine and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit constituents slightly reduces first-pass metabolism of amlodipine.
What to do
No dose change is usually needed; advise patients to report dizziness, flushing or peripheral edema if they consume large amounts of grapefruit juice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Grapefruit?
MediHelp rates the interaction as minor. Amlodipine and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice can modestly raise amlodipine concentrations by inhibiting intestinal CYP3A4. The increase is small and seldom produces a meaningful change in blood pressure or adverse effects.
How serious is the interaction between Amlodipine and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; advise patients to report dizziness, flushing or peripheral edema if they consume large amounts of grapefruit juice.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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