Drug interactions
Amlodipine + Lithium
Severity: Moderate
Amlodipine and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Case reports describe neurotoxicity such as confusion, tremor and ataxia when calcium channel blockers are combined with lithium, sometimes with normal serum lithium levels. The interaction is inconsistent and appears more often with verapamil and diltiazem than with dihydropyridines. It is rare but can be significant.
What this interaction means in plain words
Amlodipine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Why it happens
Mechanism is not established; possible additive effects on neuronal calcium handling.
What to do
Monitor for neurological symptoms such as tremor, confusion and ataxia, and check lithium levels when starting amlodipine. Reduce or stop lithium or amlodipine if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Amlodipine with Lithium?
MediHelp rates the interaction as moderate. Amlodipine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Case reports describe neurotoxicity such as confusion, tremor and ataxia when calcium channel blockers are combined with lithium, sometimes with normal serum lithium levels. The interaction is inconsistent and appears more often with verapamil and diltiazem than with dihydropyridines. It is rare but can be significant.
How serious is the interaction between Amlodipine and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurological symptoms such as tremor, confusion and ataxia, and check lithium levels when starting amlodipine. Reduce or stop lithium or amlodipine if toxicity appears.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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