Drug interactions
Amlodipine + Magnesium supplement
Severity: Minor
Amlodipine and Magnesium supplement: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has calcium-antagonist and vasodilating properties, so with amlodipine it may cause additive hypotension. Parenteral or high-dose magnesium has also been associated with neuromuscular weakness when given with calcium channel blockers. Oral supplements at usual doses rarely cause problems.
What this interaction means in plain words
Amlodipine and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive vasodilation and calcium-channel antagonism.
What to do
No routine action is needed with oral supplementation. Monitor blood pressure and neuromuscular status if high-dose or intravenous magnesium is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Magnesium supplement?
MediHelp rates the interaction as minor. Amlodipine and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium has calcium-antagonist and vasodilating properties, so with amlodipine it may cause additive hypotension. Parenteral or high-dose magnesium has also been associated with neuromuscular weakness when given with calcium channel blockers. Oral supplements at usual doses rarely cause problems.
How serious is the interaction between Amlodipine and Magnesium supplement?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with oral supplementation. Monitor blood pressure and neuromuscular status if high-dose or intravenous magnesium is used.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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