Drug interactions
Amlodipine + Metformin-sitagliptin
Severity: Minor
Amlodipine and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers such as amlodipine may slightly reduce glucose tolerance in some patients, but clinically meaningful loss of glycemic control is uncommon. Amlodipine is widely co-prescribed with metformin without problems.
What this interaction means in plain words
Amlodipine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Possible small impairment of insulin secretion by calcium channel blockade; not well established.
What to do
No routine adjustment is needed. Check glucose control periodically after starting or stopping amlodipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Amlodipine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers such as amlodipine may slightly reduce glucose tolerance in some patients, but clinically meaningful loss of glycemic control is uncommon. Amlodipine is widely co-prescribed with metformin without problems.
How serious is the interaction between Amlodipine and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Check glucose control periodically after starting or stopping amlodipine.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
