Drug interactions
Amlodipine + Metformin
Severity: Minor
Amlodipine and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly impair glucose tolerance in some patients, which could slightly reduce the glycemic effect of metformin. In practice amlodipine is generally regarded as metabolically neutral and clinically significant loss of control is uncommon.
What this interaction means in plain words
Amlodipine and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Possible pharmacodynamic opposition through reduced insulin release due to calcium channel blockade; poorly established.
What to do
No change is routinely needed. Monitor blood glucose or HbA1c as usual after starting or stopping amlodipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Metformin
Frequently asked questions
Can I take Amlodipine with Metformin?
MediHelp rates the interaction as minor. Amlodipine and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly impair glucose tolerance in some patients, which could slightly reduce the glycemic effect of metformin. In practice amlodipine is generally regarded as metabolically neutral and clinically significant loss of control is uncommon.
How serious is the interaction between Amlodipine and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is routinely needed. Monitor blood glucose or HbA1c as usual after starting or stopping amlodipine.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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