Drug interactions
Amlodipine + Metipranolol
Severity: Minor
Amlodipine and Metipranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol is an ophthalmic beta-blocker with some systemic absorption. Together with amlodipine it may cause additive hypotension or bradycardia, though this is uncommon with eye drops.
What this interaction means in plain words
Amlodipine and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive and negative chronotropic effects of systemically absorbed beta-blockade and calcium channel blockade.
What to do
Monitor heart rate and blood pressure, especially in elderly patients or those with conduction disease; use punctal occlusion to limit systemic absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Metipranolol?
MediHelp rates the interaction as minor. Amlodipine and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metipranolol is an ophthalmic beta-blocker with some systemic absorption. Together with amlodipine it may cause additive hypotension or bradycardia, though this is uncommon with eye drops.
How serious is the interaction between Amlodipine and Metipranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, especially in elderly patients or those with conduction disease; use punctal occlusion to limit systemic absorption.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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