Drug interactions
Amlodipine + Midazolam intranasal
Severity: Moderate
Amlodipine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine weakly inhibits CYP3A4 and may modestly raise midazolam exposure. This could prolong sedation or increase respiratory depression.
What this interaction means in plain words
Amlodipine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak inhibition of CYP3A4-mediated midazolam metabolism.
What to do
Monitor sedation level and respiratory status after the dose. Allow longer observation before discharge or repeat dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Amlodipine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine weakly inhibits CYP3A4 and may modestly raise midazolam exposure. This could prolong sedation or increase respiratory depression.
How serious is the interaction between Amlodipine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after the dose. Allow longer observation before discharge or repeat dosing.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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