Drug interactions
Amlodipine + Nitroprusside
Severity: Moderate
Amlodipine and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside is a potent intravenous vasodilator, and amlodipine adds to its blood pressure lowering. This can cause a greater fall in pressure than expected.
What this interaction means in plain words
Amlodipine and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide donation and calcium channel blockade.
What to do
Titrate nitroprusside with continuous arterial blood pressure monitoring and use lower infusion rates in patients taking amlodipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Nitroprusside?
MediHelp rates the interaction as moderate. Amlodipine and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroprusside is a potent intravenous vasodilator, and amlodipine adds to its blood pressure lowering. This can cause a greater fall in pressure than expected.
How serious is the interaction between Amlodipine and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate nitroprusside with continuous arterial blood pressure monitoring and use lower infusion rates in patients taking amlodipine.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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