Drug interactions
Amlodipine + Rapacuronium
Severity: Moderate
Amlodipine and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can enhance the effect of non-depolarizing neuromuscular blockers. This may prolong or deepen neuromuscular blockade during anesthesia.
What this interaction means in plain words
Amlodipine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, potentiating neuromuscular blockade.
What to do
Monitor neuromuscular function with a peripheral nerve stimulator and titrate the blocking agent to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Rapacuronium?
MediHelp rates the interaction as moderate. Amlodipine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can enhance the effect of non-depolarizing neuromuscular blockers. This may prolong or deepen neuromuscular blockade during anesthesia.
How serious is the interaction between Amlodipine and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a peripheral nerve stimulator and titrate the blocking agent to effect.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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