Drug interactions
Amlodipine-benazepril + Axitinib
Severity: Minor
Amlodipine-benazepril and Axitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is only a weak CYP3A4 inhibitor, so the rise in axitinib exposure is expected to be small. Axitinib itself commonly causes hypertension, so blood pressure control matters more than the kinetic effect.
What this interaction means in plain words
Amlodipine-benazepril and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Axitinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated axitinib metabolism by amlodipine.
What to do
No dose change is usually needed. Monitor blood pressure and axitinib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-benazepril with Axitinib?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is only a weak CYP3A4 inhibitor, so the rise in axitinib exposure is expected to be small. Axitinib itself commonly causes hypertension, so blood pressure control matters more than the kinetic effect.
How serious is the interaction between Amlodipine-benazepril and Axitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor blood pressure and axitinib adverse effects.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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