Drug interactions
Amlodipine-benazepril + Chlorpropamide
Severity: Moderate
Amlodipine-benazepril and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
What this interaction means in plain words
Amlodipine-benazepril and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Improved insulin sensitivity from ACE inhibition adds to sulfonylurea-stimulated insulin secretion.
What to do
Monitor blood glucose when benazepril is started or adjusted. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-benazepril and Chlorpropamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Amlodipine-benazepril with Chlorpropamide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
How serious is the interaction between Amlodipine-benazepril and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when benazepril is started or adjusted. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
