Drug interactions
Amlodipine-benazepril + Chlorthalidone
Severity: Moderate
Amlodipine-benazepril and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone adds to the blood pressure lowering of benazepril and amlodipine, and diuretic-induced volume depletion can cause first-dose hypotension and reduced renal function. The combination is commonly used, but needs monitoring.
What this interaction means in plain words
Amlodipine-benazepril and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects with volume depletion plus ACE inhibition reducing glomerular filtration pressure.
What to do
Monitor blood pressure, creatinine and electrolytes after starting or changing doses. Correct volume depletion and adjust the diuretic dose if hypotension or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Amlodipine-benazepril with Chlorthalidone?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone adds to the blood pressure lowering of benazepril and amlodipine, and diuretic-induced volume depletion can cause first-dose hypotension and reduced renal function. The combination is commonly used, but needs monitoring.
How serious is the interaction between Amlodipine-benazepril and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and electrolytes after starting or changing doses. Correct volume depletion and adjust the diuretic dose if hypotension or renal decline occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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