Drug interactions
Amlodipine-benazepril + Clozapine
Severity: Moderate
Amlodipine-benazepril and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine frequently causes orthostatic hypotension, particularly during titration, and antihypertensives can worsen this. Syncope and falls may result, and rarely circulatory collapse.
What this interaction means in plain words
Amlodipine-benazepril and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Clozapine belongs to Central Nervous System.
Why it happens
Additive hypotension from clozapine alpha-1 adrenergic blockade and antihypertensive effects.
What to do
Titrate clozapine slowly and monitor blood pressure and heart rate. Reduce antihypertensive doses if orthostatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Amlodipine-benazepril with Clozapine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine frequently causes orthostatic hypotension, particularly during titration, and antihypertensives can worsen this. Syncope and falls may result, and rarely circulatory collapse.
How serious is the interaction between Amlodipine-benazepril and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clozapine slowly and monitor blood pressure and heart rate. Reduce antihypertensive doses if orthostatic hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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