Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Epoprostenol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator and can cause hypotension, which may be additive with the antihypertensive components. Patients may experience dizziness or symptomatic low blood pressure.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering.
What to do
Monitor blood pressure closely when starting or titrating epoprostenol and reduce antihypertensive therapy if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Epoprostenol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator and can cause hypotension, which may be additive with the antihypertensive components. Patients may experience dizziness or symptomatic low blood pressure.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when starting or titrating epoprostenol and reduce antihypertensive therapy if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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