Drug interactions
Amlodipine-benazepril + Imipramine
Severity: Moderate
Amlodipine-benazepril and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine causes orthostatic hypotension through alpha-1 blockade, which adds to the effects of amlodipine and benazepril. Falls and syncope are a concern, particularly in older adults.
What this interaction means in plain words
Amlodipine-benazepril and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from alpha-adrenergic blockade by the tricyclic antidepressant.
What to do
Monitor orthostatic blood pressure when starting imipramine and reduce doses or change agents if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Imipramine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine causes orthostatic hypotension through alpha-1 blockade, which adds to the effects of amlodipine and benazepril. Falls and syncope are a concern, particularly in older adults.
How serious is the interaction between Amlodipine-benazepril and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting imipramine and reduce doses or change agents if symptomatic.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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