Drug interactions
Amlodipine-benazepril + Isocarboxazid
Severity: Moderate
Amlodipine-benazepril and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors commonly cause orthostatic hypotension, and combining them with antihypertensives such as amlodipine and benazepril can produce excessive blood pressure reduction. Falls and syncope are the main concerns.
What this interaction means in plain words
Amlodipine-benazepril and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive hypotensive effects arise from MAOI-related autonomic blockade and the vasodilating actions of the calcium channel blocker and ACE inhibitor.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce antihypertensive doses if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Isocarboxazid?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors commonly cause orthostatic hypotension, and combining them with antihypertensives such as amlodipine and benazepril can produce excessive blood pressure reduction. Falls and syncope are the main concerns.
How serious is the interaction between Amlodipine-benazepril and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce antihypertensive doses if orthostatic symptoms develop.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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