Drug interactions
Amlodipine-benazepril + Isoflurane
Severity: Moderate
Amlodipine-benazepril and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane causes dose-dependent vasodilation and myocardial depression, and in patients taking amlodipine and benazepril this can produce marked intraoperative hypotension. ACE inhibitors in particular are associated with refractory hypotension under general anesthesia.
What this interaction means in plain words
Amlodipine-benazepril and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Isoflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation and reduced vascular tone from volatile anesthetic, calcium channel blockade and suppressed angiotensin II.
What to do
Inform the anesthesia team of the antihypertensives and consider holding the ACE inhibitor on the morning of surgery per local protocol. Monitor blood pressure closely and treat hypotension with fluids and vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Amlodipine-benazepril with Isoflurane?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane causes dose-dependent vasodilation and myocardial depression, and in patients taking amlodipine and benazepril this can produce marked intraoperative hypotension. ACE inhibitors in particular are associated with refractory hypotension under general anesthesia.
How serious is the interaction between Amlodipine-benazepril and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of the antihypertensives and consider holding the ACE inhibitor on the morning of surgery per local protocol. Monitor blood pressure closely and treat hypotension with fluids and vasopressors.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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