Drug interactions
Amlodipine-benazepril + Isosorbide dinitrate
Severity: Moderate
Amlodipine-benazepril and Isosorbide dinitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates cause venous and arterial dilation, and adding amlodipine and benazepril increases the likelihood of symptomatic hypotension, dizziness or syncope. The effect is often tolerated but is more notable in older or volume-depleted patients.
What this interaction means in plain words
Amlodipine-benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Additive vasodilation through nitric oxide-mediated smooth muscle relaxation, calcium channel blockade and reduced angiotensin II.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing doses. Adjust doses of antihypertensives if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Amlodipine-benazepril with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates cause venous and arterial dilation, and adding amlodipine and benazepril increases the likelihood of symptomatic hypotension, dizziness or syncope. The effect is often tolerated but is more notable in older or volume-depleted patients.
How serious is the interaction between Amlodipine-benazepril and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing doses. Adjust doses of antihypertensives if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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