Drug interactions
Amlodipine-benazepril + Ketoconazole
Severity: Moderate
Amlodipine-benazepril and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits CYP3A4 and can raise amlodipine concentrations, leading to more hypotension, flushing and peripheral edema. The effect is generally modest but may matter in older patients.
What this interaction means in plain words
Amlodipine-benazepril and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism in the liver and gut wall increases amlodipine exposure.
What to do
Monitor blood pressure and edema when ketoconazole is started or stopped. Reduce the amlodipine dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Ketoconazole?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole inhibits CYP3A4 and can raise amlodipine concentrations, leading to more hypotension, flushing and peripheral edema. The effect is generally modest but may matter in older patients.
How serious is the interaction between Amlodipine-benazepril and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when ketoconazole is started or stopped. Reduce the amlodipine dose if hypotension or adverse effects occur.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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