Drug interactions
Amlodipine-benazepril + Larotrectinib
Severity: Minor
Amlodipine-benazepril and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is partly metabolized by CYP3A4 and is a weak to moderate inhibitor of it in vitro. Amlodipine exposure could rise slightly, though the effect has not been well characterized clinically.
What this interaction means in plain words
Amlodipine-benazepril and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib decreasing amlodipine metabolism.
What to do
No empirical dose adjustment is needed. Monitor blood pressure and for peripheral edema after starting larotrectinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Amlodipine-benazepril with Larotrectinib?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is partly metabolized by CYP3A4 and is a weak to moderate inhibitor of it in vitro. Amlodipine exposure could rise slightly, though the effect has not been well characterized clinically.
How serious is the interaction between Amlodipine-benazepril and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor blood pressure and for peripheral edema after starting larotrectinib.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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