Drug interactions
Amlodipine-benazepril + Morphine
Severity: Minor
Amlodipine-benazepril and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine can cause vasodilation and histamine-related blood pressure drops, and this adds to the effect of the antihypertensive combination. Patients may experience low blood pressure or dizziness, especially when starting therapy or increasing doses.
What this interaction means in plain words
Amlodipine-benazepril and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Morphine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic hypotensive effects of opioid-induced vasodilation and the vasodilating actions of amlodipine and benazepril.
What to do
Monitor blood pressure and counsel patients to rise slowly after opioid initiation or dose increases. Reduce the opioid dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Amlodipine-benazepril with Morphine?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Morphine can cause vasodilation and histamine-related blood pressure drops, and this adds to the effect of the antihypertensive combination. Patients may experience low blood pressure or dizziness, especially when starting therapy or increasing doses.
How serious is the interaction between Amlodipine-benazepril and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients to rise slowly after opioid initiation or dose increases. Reduce the opioid dose if symptomatic hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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