Drug interactions
Amlodipine-benazepril + Naproxen
Severity: Moderate
Amlodipine-benazepril and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of ACE inhibitors and impair renal function. The risk is highest in older patients, those who are volume depleted, or with existing renal impairment.
What this interaction means in plain words
Amlodipine-benazepril and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces renal vasodilation and sodium excretion, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Use the lowest effective NSAID dose for the shortest time, and ensure adequate hydration. Monitor blood pressure and serum creatinine and potassium, or choose paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-benazepril and Naproxen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Amlodipine-benazepril with Naproxen?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of ACE inhibitors and impair renal function. The risk is highest in older patients, those who are volume depleted, or with existing renal impairment.
How serious is the interaction between Amlodipine-benazepril and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, and ensure adequate hydration. Monitor blood pressure and serum creatinine and potassium, or choose paracetamol where suitable.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
