Drug interactions
Amlodipine-benazepril + Phenelzine
Severity: Moderate
Amlodipine-benazepril and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine, an MAO inhibitor, often causes orthostatic hypotension, which may be worsened by antihypertensives. Syncope and falls are possible.
What this interaction means in plain words
Amlodipine-benazepril and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Why it happens
Additive hypotension from MAO inhibitor-related autonomic effects and antihypertensive actions.
What to do
Monitor supine and standing blood pressure, and reduce antihypertensive doses if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Phenelzine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenelzine, an MAO inhibitor, often causes orthostatic hypotension, which may be worsened by antihypertensives. Syncope and falls are possible.
How serious is the interaction between Amlodipine-benazepril and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure, and reduce antihypertensive doses if orthostatic symptoms develop.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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