Drug interactions
Amlodipine-benazepril + Rufinamide
Severity: Minor
Amlodipine-benazepril and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak inducer of CYP3A4 and may slightly reduce concentrations of CYP3A4 substrates like amlodipine. The effect on blood pressure control is likely small.
What this interaction means in plain words
Amlodipine-benazepril and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Rufinamide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by rufinamide increases amlodipine clearance.
What to do
Monitor blood pressure after starting or stopping rufinamide. Raise the amlodipine dose only if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Rufinamide?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak inducer of CYP3A4 and may slightly reduce concentrations of CYP3A4 substrates like amlodipine. The effect on blood pressure control is likely small.
How serious is the interaction between Amlodipine-benazepril and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping rufinamide. Raise the amlodipine dose only if control is inadequate.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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