Drug interactions
Amlodipine-benazepril + Spironolactone
Severity: Major
Amlodipine-benazepril and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone and spironolactone blocks its receptor, so the two together can cause marked potassium retention. Severe hyperkalemia and arrhythmias can occur, especially with renal impairment or diabetes.
What this interaction means in plain words
Amlodipine-benazepril and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Additive reduction in renal potassium excretion via suppressed aldosterone production and mineralocorticoid receptor blockade.
What to do
Check serum potassium and creatinine at baseline, within the first week or so, and periodically thereafter. Avoid potassium supplements and reduce or stop spironolactone if potassium rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Amlodipine-benazepril with Spironolactone?
MediHelp rates the interaction as major. Amlodipine-benazepril and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors reduce aldosterone and spironolactone blocks its receptor, so the two together can cause marked potassium retention. Severe hyperkalemia and arrhythmias can occur, especially with renal impairment or diabetes.
How serious is the interaction between Amlodipine-benazepril and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline, within the first week or so, and periodically thereafter. Avoid potassium supplements and reduce or stop spironolactone if potassium rises significantly.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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