Drug interactions
Amlodipine-benazepril + Tolmetin
Severity: Moderate
Amlodipine-benazepril and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin, an NSAID, can blunt the blood pressure-lowering effect of benazepril. Together they may also reduce renal function, particularly in older, volume-depleted or already renally impaired patients, and can cause acute kidney injury.
What this interaction means in plain words
Amlodipine-benazepril and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit synthesis of vasodilatory renal prostaglandins, which opposes ACE inhibitor effects and lowers glomerular filtration pressure.
What to do
Prefer a non-NSAID analgesic such as paracetamol where possible. If an NSAID is needed, keep hydration adequate and monitor blood pressure, serum creatinine and potassium after starting and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Amlodipine-benazepril with Tolmetin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin, an NSAID, can blunt the blood pressure-lowering effect of benazepril. Together they may also reduce renal function, particularly in older, volume-depleted or already renally impaired patients, and can cause acute kidney injury.
How serious is the interaction between Amlodipine-benazepril and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as paracetamol where possible. If an NSAID is needed, keep hydration adequate and monitor blood pressure, serum creatinine and potassium after starting and during therapy.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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