Drug interactions
Amlodipine-benazepril + Tretinoin
Severity: Minor
Amlodipine-benazepril and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic tretinoin has been associated with hypotension and other cardiovascular effects, including differentiation syndrome in leukemia treatment. Combined use may add to blood pressure lowering.
What this interaction means in plain words
Amlodipine-benazepril and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive hypotensive effects; the mechanism for tretinoin-related hypotension is not well established.
What to do
Monitor blood pressure during tretinoin therapy. Hold or reduce antihypertensives if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Amlodipine-benazepril with Tretinoin?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic tretinoin has been associated with hypotension and other cardiovascular effects, including differentiation syndrome in leukemia treatment. Combined use may add to blood pressure lowering.
How serious is the interaction between Amlodipine-benazepril and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during tretinoin therapy. Hold or reduce antihypertensives if hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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