Drug interactions
Amlodipine-benazepril + Triamterene
Severity: Major
Amlodipine-benazepril and Triamterene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both benazepril and triamterene reduce potassium excretion, so combined use can cause significant hyperkalemia. The risk is higher with renal impairment, diabetes or older age.
What this interaction means in plain words
Amlodipine-benazepril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone while triamterene blocks epithelial sodium channels, both reducing renal potassium loss.
What to do
Avoid the combination where possible; if used, monitor serum potassium and renal function frequently. Avoid potassium supplements and salt substitutes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Amlodipine-benazepril with Triamterene?
MediHelp rates the interaction as major. Amlodipine-benazepril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both benazepril and triamterene reduce potassium excretion, so combined use can cause significant hyperkalemia. The risk is higher with renal impairment, diabetes or older age.
How serious is the interaction between Amlodipine-benazepril and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and renal function frequently. Avoid potassium supplements and salt substitutes.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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