Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Arformoterol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Arformoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol can lower serum potassium and prolong QT in some patients, and hydrochlorothiazide adds to potassium loss. Hypokalemia may increase the risk of arrhythmias.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Arformoterol belongs to Respiratory.
Why it happens
Beta-2 agonist intracellular potassium shift combined with thiazide renal potassium wasting.
What to do
Monitor serum potassium and magnesium, especially in patients with cardiac disease or at higher doses. Replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Arformoterol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol can lower serum potassium and prolong QT in some patients, and hydrochlorothiazide adds to potassium loss. Hypokalemia may increase the risk of arrhythmias.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Arformoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially in patients with cardiac disease or at higher doses. Replace electrolytes as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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