Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Artemether / lumefantrine
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Artemether / lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 inducing activity and may modestly lower amlodipine concentrations. With a short antimalarial course the effect on blood pressure is likely to be small and temporary.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak induction of CYP3A4-mediated amlodipine metabolism.
What to do
No empirical dose change is needed; check blood pressure during and after the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Artemether / lumefantrine?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has weak CYP3A4 inducing activity and may modestly lower amlodipine concentrations. With a short antimalarial course the effect on blood pressure is likely to be small and temporary.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Artemether / lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; check blood pressure during and after the antimalarial course.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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