Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Aspirin rectal
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Aspirin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin at analgesic doses can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide and impair renal function in volume-depleted patients. Effects are dose and duration dependent.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion.
What to do
Limit the dose and duration of rectal aspirin and maintain hydration. Monitor blood pressure and renal function if used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Aspirin rectal?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin at analgesic doses can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide and impair renal function in volume-depleted patients. Effects are dose and duration dependent.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Aspirin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the dose and duration of rectal aspirin and maintain hydration. Monitor blood pressure and renal function if used regularly.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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