Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Bendroflumethiazide
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Bendroflumethiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendroflumethiazide duplicates the thiazide component already in the combination, increasing diuresis, hypokalemia, hyponatremia, hypotension and hyperuricemia. The valsartan component only partly offsets potassium loss.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Bendroflumethiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Therapeutic duplication of thiazide diuretics produces additive natriuresis and potassium wasting.
What to do
Avoid using two thiazide diuretics together; stop one of them. If unavoidable, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Bendroflumethiazide?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Bendroflumethiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bendroflumethiazide duplicates the thiazide component already in the combination, increasing diuresis, hypokalemia, hyponatremia, hypotension and hyperuricemia. The valsartan component only partly offsets potassium loss.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Bendroflumethiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide diuretics together; stop one of them. If unavoidable, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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