Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Buprenorphine long-acting
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Buprenorphine long-acting: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may promote antidiuretic hormone release and can blunt the diuretic effect of hydrochlorothiazide, and can also add to hypotension. The effect is usually small and variable with the long-acting injection.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Buprenorphine long-acting have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-related antidiuretic hormone release and additive hypotensive effects reduce diuretic efficacy and may affect blood pressure.
What to do
Monitor blood pressure, fluid status and edema. Adjust the diuretic dose only if the effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Buprenorphine long-acting?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Buprenorphine long-acting have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids may promote antidiuretic hormone release and can blunt the diuretic effect of hydrochlorothiazide, and can also add to hypotension. The effect is usually small and variable with the long-acting injection.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Buprenorphine long-acting?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and edema. Adjust the diuretic dose only if the effect is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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