Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Butabarbital
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate that induces CYP3A4 and may lower amlodipine concentrations, weakening blood pressure control. Barbiturates can also add to orthostatic hypotension.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure when starting or stopping butabarbital and increase the amlodipine dose if needed. Reassess the dose when the barbiturate is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Butabarbital?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate that induces CYP3A4 and may lower amlodipine concentrations, weakening blood pressure control. Barbiturates can also add to orthostatic hypotension.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping butabarbital and increase the amlodipine dose if needed. Reassess the dose when the barbiturate is discontinued.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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