Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Butalbital
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may induce CYP3A4 and lower amlodipine levels, though intermittent use limits the effect. Barbiturates can also add to orthostatic hypotension.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure if butalbital is used frequently, and adjust amlodipine if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Butalbital?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital, a barbiturate, may induce CYP3A4 and lower amlodipine levels, though intermittent use limits the effect. Barbiturates can also add to orthostatic hypotension.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if butalbital is used frequently, and adjust amlodipine if control worsens.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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